Pancreatic Stellate Cells and Metabolic Alteration: Physiology and Pathophysiology
Pancreatic stellate cells play a pivotal role in the development of pancreatic fibrosis.A wide variety of external stimuli can cause PSC activation accompanied by metabolic changes, which alters the tissue microenvironment by producing extracellular matrix proteins, cytokines, growth factors, and other mediators.Several metabolites aggravate fibros